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lt is generally difficult to manage interactions between pharmacological compounds. The aim of this work is to assist the pharmacist in the management of interactions involving an antacid, H2-antihistamine or an inhibitor of the proton pump. The timing of administration of these three classes of drugs is defined and justified on the basis of the scientific literature. The association with other drugs complicates the recommended schedule of administration. In this thesis, the mechanisms involved are developed, the consequences are mentioned and solutions are proposed in order to circumvent these interactions. The ultimate goal is to provide a reasoned and useful answer to professional practice. De façon générale, il est difficile de gérer les interactions. Ce mémoire a pour but d'aider le pharmacien d'officine dans la gestion des interactions impliquant un antiacide, un antihistaminique-H2 ou un inhibiteur de la pompe à proton. Les moments de prise de ces trois familles de médicaments sont définis et justifiés sur base de la littérature scientifique. L'association avec d'autres médicaments complique le schéma de prise habituel des médicaments impliqués. Dans ce mémoire, les mécanismes d'interaction sont développés, les conséquences sont citées et des solutions sont apportées afin de contourner l'interaction . Le but final étant d'apporter une réponse argumentée et utile à la pratique professionnelle.
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Following centuries of debate about "nature and nurture", the discovery of DNA established the idea that nature (genes) determines who we are, relegating nurture (environment) to icing on the cake. Since the 1950s, the new science of epigenetics has demonstrated how environments, external and internal to individual bodies, influence gene expression at the molecular level, with significant implications for health and wellbeing. To the amazement of scientists, mapping the human genome indirectly supported these insights. Anthropologists Margaret Lock and Gisli Palsson outline vituperative arguments from classical times about the relationship between nature and nurture, furthered today by epigenetic findings and the demonstration of a "reactive genome." The nature/nurture debate, they show, can never be put to rest, because these concepts are in constant flux in response to the new insights science continually offers
Sociology of knowledge --- Evolution. Phylogeny --- Individuality --- Genetics, Behavioral --- Gene-Environment Interaction --- Heredity --- Social Environment --- Science
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Mental Disorders --- Gene-Environment Interaction. --- Genetic Predisposition to Disease. --- genetics. --- Predisposition, Genetic --- Susceptibility, Genetic --- Genetic Predisposition --- Genetic Susceptibility --- Genetic Predispositions --- Genetic Susceptibilities --- Predispositions, Genetic --- Susceptibilities, Genetic --- Disease Susceptibility --- Genetic Testing --- Anticipation, Genetic --- Genetic Association Studies --- Gene-Environment Interaction --- Environment-Gene Interaction --- Environment Gene Interaction --- Environment-Gene Interactions --- Gene Environment Interaction --- Gene-Environment Interactions --- Interaction, Environment-Gene --- Interaction, Gene-Environment --- Interactions, Environment-Gene --- Interactions, Gene-Environment --- Genetic Predisposition to Disease --- Ecotype --- genetics
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Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence-genetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G x E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use.
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Obesity --- Gene-Environment Interaction --- Genetic Predisposition to Disease --- Genetics --- Medical. --- Chemistry --- Health Sciences --- Biochemistry --- Pathology --- Genetics, Medical --- Genetic Structures --- Genetic Phenomena --- Human Genetics --- Medical Genetics --- Genetics, Human --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Periodicals
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Does your family make you smarter? James R. Flynn presents an exciting new method for estimating the effects of family on a range of cognitive abilities. Rather than using twin and adoption studies, he analyses IQ tables that have been hidden in manuals over the last 65 years, and shows that family environment can confer a significant advantage or disadvantage to your level of intelligence. Wading into the nature vs. nurture debate, Flynn banishes the pessimistic notion that by the age of seventeen, people's cognitive abilities are solely determined by their genes. He argues that intelligence is also influenced by human autonomy - genetics and family notwithstanding, we all have the capacity to choose to enhance our cognitive performance. He concludes by reconciling this new understanding of individual differences with his earlier research on intergenerational trends (the 'Flynn effect') culminating in a general theory of intelligence.
Families. --- Family. --- Gene-Environment Interaction. --- Genetic psychology. --- Human beings --- Human genetics. --- Individuality. --- Intellect. --- Intelligence Tests. --- Intelligence --- Nature and nurture. --- Social Environment. --- Effect of environment on. --- Genetics. --- Human genetics --- Psychology
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Vegetables --- Genotype-environment interaction --- Phenotype --- Genotype-environment interaction. --- Phenotype. --- Genetics --- Genetics. --- Phenotypes --- Gene-environment interaction --- Genotype by environment interaction --- Genotype (times) environment interaction --- Genotype x environment interaction --- Interaction of environment and genotype --- Food crops --- Horticultural crops --- Horticultural products
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Depuis le lancement du programme de séquençage du génome humain, le développement continu des technologies et des langages génétiques a fait émerger une riche littérature au croisement de la sociologie, de l’anthropologie et de la philosophie s’interrogeant sur la place grandissante acquise par le gène dans nos sociétés. Si la notion de génétisation s’y est imposée comme schème interprétatif critique des processus en jeu, celle-ci se voit aujourd’hui en partie dépassée consécutivement au développement de nouvelles modalités de diffusion des technologies génétiques. L’apparition d’une offre d’autotests génétiques par le biais d’Internet laisse en effet apparaître une autonomisation de la dynamique de génétisation au sein de la société, soit l’émergence d’une auto-génétisation à l’heure où la génomique en vient à se pratiquer en version Do-It-Yourself. Sur la base d’une enquête par observations ethnographiques de divers espaces numériques et d’entretiens, il ressort que des publics grandissants se voient désormais acquis à l’intérêt qu’il y aurait à s’orienter vers les gènes pour pouvoir se constituer un « capital santé » ou un « capital généalogique ». Au cœur de cette dynamique où le génétique en vient à englober des domaines en expansion, touchant tout autant à la santé qu’à la construction de l’identité, la génétisation n’apparaît plus seulement comme une opération de nature intellectuelle conduisant à valoriser le rôle des gènes face aux facteurs dits d’environnement, mais aussi et surtout comme une entreprise pratique au cours de laquelle l’individu en vient à se tourner vers ses gènes pour faire face à un environnement devenu incertain.
Gene-Environment Interaction --- Genetics, Human --- Epigenomics --- Environmental Exposure --- Anthropology, Medical --- Genotype-environment interaction. --- Human Genetics. --- Génétique humaine --- Interaction gène-environnement --- Épigénétique. --- Épigénétique --- Génétique médicale --- Aspect social. --- Interaction gène-environnement. --- Génétique médicale. --- Human genetics. --- Medical anthropology --- Epigenomics. --- Environmental Exposure. --- Anthropology, Medical. --- Sociology --- sociologie --- médecine --- santé
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Our modern lifestyles, city-bound with abundant nutrition - are far removed from the hunter-gatherer lifestyles of our ancestors. However we have not evolved to reflect this change. This fascinating and controversial book explores whether it is this 'mismatch' that has led to the deadly explosion in lifestyle diseases we face today. - ;We have built a world that no longer fits our bodies. Our genes - selected through our evolution - and the many processes by which our development is tuned within the womb, limit our capacity to adapt to the modern urban lifestyle. There is a mismatch. We are se
Ecological genetics. --- Evolution (Biology) --- Genotype-environment interaction. --- Gene-environment interaction --- Genotype by environment interaction --- Genotype (times) environment interaction --- Genotype x environment interaction --- Interaction of environment and genotype --- Genetics --- Phenotype --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Ecology
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In his new preface E. O. Wilson reflects on how he came to write this book: how The Insect Societies led him to write Sociobiology, and how the political and religious uproar that engulfed that book persuaded him to write another book that would better explain the relevance of biology to the understanding of human behavior.
Sociobiology. --- Social Darwinism. --- Darwinism, Social --- Competition --- Social change --- Social conflict --- Social evolution --- Biologism --- Human biology --- Human evolution --- Psychology, Comparative --- Social aspects --- aggression. --- altruism. --- behavioral genetics. --- bioethics. --- biological determinism. --- biology sexual orientation. --- cultural evolution. --- discrimination. --- gene environment interaction. --- heredity. --- human diversity. --- natural selection. --- nature v nurture. --- pulitzer prize. --- religion. --- social darwinism. --- sociobiology.
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